Meet the jury seminar: From Mechanisms to Therapies: A Journey Through Hereditary Neuropathies

The seminar will explore how understanding the molecular mechanisms underlying hereditary neuropathies can pave the way for new targeted therapies. Focusing on Charcot-Marie-Tooth disease, Prof. D’Antonio will show how different genetic mutations can affect peripheral nerves through distinct mechanisms, ranging from protein misfolding and cellular stress to disrupted axonal metabolism and transport. Drawing on studies in genetically modified models, he will discuss how targeting these disease mechanisms can improve myelination, nerve function and neuroprotection, ultimately contributing to the development of more targeted and patient-specific treatments for hereditary neuropathies.